Pulmonary Vasodilator Therapy in the NICU: Inhaled Nitric Oxide, Sildenafil, and Other Pulmonary Vasodilating Agents
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چکیده
منابع مشابه
Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide.
BACKGROUND The prognosis of patients with severe pulmonary hypertension (PHT) is poor. To determine prognosis and guide therapy, an acute hemodynamic trial of selective pulmonary vasodilators, usually inhaled nitric oxide (iNO), was performed. We hypothesized that oral sildenafil, a phosphodiesterase-5 inhibitor, is a safe and effective alternative to iNO. METHODS AND RESULTS We studied 13 co...
متن کاملPulmonary Arterial Hypertension : Comparison With Inhaled Nitric Oxide Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With
Evangelos Michelakis, Wayne Tymchak, Dale Lien, Linda Webster, Kyoko Hashimoto and Pulmonary Arterial Hypertension : Comparison With Inhaled Nitric Oxide Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Associa...
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Inhaled nitric oxide (NO) is a selective pulmonary vasodilator in adult and pediatric patients. Inhaled NO diffuses into the pulmonary vascular smooth muscle where it results in vasodilation via stimulation of guanylyl cyclase. Systemic hemodynamics are not altered because inhaled NO is rapidly inactivated by hemoglobin. Oxygenation is also increased in certain patients as inhaled NO only vasod...
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Phosphodiesterase 1 (PDE1) modulates vascular tone and the development of tolerance to nitric oxide (NO)-releasing drugs in the systemic circulation. Any role of PDE1 in the pulmonary circulation remains largely uncertain. We measured the expression of genes encoding PDE1 isozymes in the pulmonary vasculature and examined whether or not selective inhibition of PDE1 by vinpocetine attenuates pul...
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ژورنال
عنوان ژورنال: Clinics in Perinatology
سال: 2012
ISSN: 0095-5108
DOI: 10.1016/j.clp.2011.12.006